Peritonectomy and peritonealcarcinoses
Cytoreductive surgery means a complete removal of all visible
tumors into the peritoneal cavity. It requires peritonectomy
procedures eventually associated with multiple intestinal and/or
organ resection.
The present knowledge of cell-kill kinetics with cytotoxic drugs
indicates that, due to a larger proportion of cell growth fraction,
micrometastases are more susceptible to chemotherapy than
macroscopic ones, so that cancer cells free in the peritoneal cavity
represent an ideal target of a locoregional treatment consisting in a
high concentrated administration of cytotoxic drugs under
hyperthermic conditions.
For the combination of hyperthermia and chemotherapy, spatial cooperation can explain the additive effects.
- the efficacy of many drugs is potentiated by heat.
- the addition of hyperthermia to chemotherapy can counteract drug resistance.
- Increase in intracellular drug uptake
- enhanced DNA damage
- increase in intratumour drug concentrations, resulting from an increase in blood flow.
- non invasive peritoneal carcinoses or sarcomatoses
- peritoneal mesothelioma
- limited peritonealcarcinose with invasive tumors
- perforated primary gastrointestinal carcinoma
- primary T4- gastrointestinal carcinome
- primary gastrointestial Carcinome with positiv peritoneal cytology
- Palliation von Patienten mit malignem Aszites
Informationen HIPEC
- Pathophysiology of the peritoneum
- Tumor Cell Entrapment Peritonealcarcinoses
- Surgery on Peritonealcarcinoses
- Technique of intraperitoneal chemotherapy
- Pharmacokinetic aspects of intraperitoneal chemotherapy
- Definitions
- Diagnostics of peritoneal carcinosis
- Hyperthermia with peritonectomy
- clinical results of Cytoreductive surgery and hyperthermic chemotherapy
- Survey
- Peritoneal carcinoses results after therapy
- References